MicroRNA-133b/EGFR axis regulates esophageal squamous cell carcinoma metastases by suppressing anoikis resistance and anchorage-independent growth
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چکیده
منابع مشابه
CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance
Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression ...
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متن کاملSuppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma.
The gene of SKP2, located on chromosome 5p13, plays a critical role in cell cycle progression, especially at the G(1)-S transition, putatively through its control of several cell cycle regulator proteins including p27(kip1), p21(cip1), p57(kip2), p130, cyclin E, and c-Myc. Previous studies in this laboratory revealed that gain of chromosome 5p was often seen in esophageal squamous cell carcinom...
متن کاملOvercoming anoikis--pathways to anchorage-independent growth in cancer.
Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use to eliminate 'misplaced' cells, i.e. cells that are in an inappropriate location. Occasionally, detached or misplaced cells can overcome anoikis and survive for a certain period of time in the absence of the correct signals from the extracellular matrix (ECM). If cells are able to adapt to their new env...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2018
ISSN: 1475-2867
DOI: 10.1186/s12935-018-0684-y